Pub. Date : 1997 Jul 1
PMID : 9200434
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This second mechanism for inhibiting proliferation is probably inhibition of protein tyrosine kinases, since these higher concentrations of A77 1726 inhibit IL-2-induced tyrosine phosphorylation of Jak1 and Jak3, the protein tyrosine kinases initiating signaling by the IL-2R. | Tyrosine | interleukin 2 | Mus musculus |
| 2 | Tyrosine phosphorylation of the beta-chain of the IL-2R, which is required for IL-2-driven proliferation, is also inhibited by A77 1726. | Tyrosine | interleukin 2 | Mus musculus |