Title : Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution.

Pub. Date : 1997 Jul

PMID : 9199341






1 Functional Relationships(s)
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1 Addition of estradiol relieves the cell cycle block created by tamoxifen treatment, leading to marked activation of cyclin E-cdk2 complexes and phosphorylation of the retinoblastoma protein within 6 h. Cyclin D1 levels increase significantly while the levels of cyclin E, cdk2, and the p21 and p27 cdk inhibitors are relatively constant. Tamoxifen H3 histone pseudogene 16 Homo sapiens