Title : c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.

Pub. Date : 1997 Jun 24

PMID : 9192621






2 Functional Relationships(s)
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1 Stably transfected Rat1a fibroblasts that overexpress LDH-A alone or those transformed by c-Myc overproduce lactic acid. Lactic Acid MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Our studies have linked c-Myc to the induction of LDH-A, whose expression increases lactate production and is necessary for c-Myc-mediated transformation. Lactic Acid MYC proto-oncogene, bHLH transcription factor Homo sapiens