Pub. Date : 1997 Jun
PMID : 9191080
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Four days of ethanol exposure enhanced carbachol-stimulated c-fos mRNA expression, analyzed with Northern blot, and Fos/AP-1 binding activity, measured with gel mobility super shift assay. | Carbachol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Pre-incubation with muscarinic antagonists or the protein kinase C inhibitor GF109203X demonstrated that, in both control and ethanol-treated cells, carbachol-induced c-fos expression was mediated via muscarinic M1 receptors and to a large extent through protein kinase C. However, phorbol ester-induced c-fos expression was unaffected in ethanol-treated cells. | Carbachol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Pre-incubation with muscarinic antagonists or the protein kinase C inhibitor GF109203X demonstrated that, in both control and ethanol-treated cells, carbachol-induced c-fos expression was mediated via muscarinic M1 receptors and to a large extent through protein kinase C. However, phorbol ester-induced c-fos expression was unaffected in ethanol-treated cells. | Carbachol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | Acute exposure to ethanol caused a suppression of both carbachol- and phorbol ester-stimulated c-fos expression. | Carbachol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |