Title : Protein synthesis inhibitor cycloheximide dose-dependently decreases formalin-induced c-Fos protein and behavioral hyperalgesia in rats.

Pub. Date : 1997 May 16

PMID : 9180213






3 Functional Relationships(s)
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1 Protein synthesis inhibitor cycloheximide dose-dependently decreases formalin-induced c-Fos protein and behavioral hyperalgesia in rats. Cycloheximide Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 To test whether de novo protein synthesis is required for the development of persistent pain after peripheral inflammation, we observed formalin-induced spinal c-Fos protein and nociceptive behaviors following pretreatment with cycloheximide, a protein synthesis inhibitor. Cycloheximide Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 Cycloheximide dose-dependently inhibited formalin-induced spinal c-Fos protein and tonic nociceptive responses. Cycloheximide Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus