Title : Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine.

Pub. Date : 1997 Jun 13

PMID : 9180079






1 Functional Relationships(s)
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1 Screening libraries of variants of one of these families under affinity-selective conditions yielded a 14-amino acid peptide (Ile-Glu-Gly-Pro-Thr-Leu-Arg-Gln-Trp-Leu-Ala-Ala-Arg-Ala) with high affinity (dissociation constant approximately 2 nanomolar) that stimulates the proliferation of a TPO-responsive Ba/F3 cell line with a median effective concentration (EC50) of 400 nanomolar. Arginine thrombopoietin Homo sapiens