Title : Secretion of N-(4-hydroxyphenyl) retinamide-retinol-binding protein from liver parenchymal cells: evidence for reduced affinity of the complex for transthyretin.

Pub. Date : 1997 May 16

PMID : 9178822






6 Functional Relationships(s)
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1 The synthetic retinoid 4-HPR has been shown to markedly lower the plasma concentration of both retinol and RBP in rats and humans. Vitamin A haptoglobin-related protein Homo sapiens
2 We have studied the effect of 4-HPR on the secretion of retinol-RBP from liver cells in vivo and in vitro. Vitamin A haptoglobin-related protein Homo sapiens
3 In control rats, the lymph-derived [3H]retinol peaked after about 2 hr, whereas 4-HPR treatment effectively reduced this peak of [3H]retinol. Vitamin A haptoglobin-related protein Homo sapiens
4 Our results suggest that 4-HPR inhibits secretion of retinol-RBP from the liver. Vitamin A haptoglobin-related protein Homo sapiens
5 When the medium from cells incubated with either 4-HPR or retinol was applied to a TTR affinity column, we found that RBP from cells incubated with 4-HPR had a considerably reduced affinity for TTR. Vitamin A haptoglobin-related protein Homo sapiens
6 This observation may explain the 4-HPR-induced reduction of plasma retinol and RBP observed in in vivo studies. Vitamin A haptoglobin-related protein Homo sapiens