Title : The protein kinase A pathway inhibits c-jun and c-fos protooncogene expression induced by the protein kinase C and tyrosine kinase pathways in cultured human thyroid follicles.

Pub. Date : 1997 Jun

PMID : 9177393






2 Functional Relationships(s)
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1 The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein. Tetradecanoylphorbol Acetate protein tyrosine kinase 2 beta Homo sapiens
2 This indicates a PKC- and PTK-mediated pathway triggered by TPA and EGF, respectively. Tetradecanoylphorbol Acetate protein tyrosine kinase 2 beta Homo sapiens