Title : Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis.

Pub. Date : 1997 May

PMID : 9176845






4 Functional Relationships(s)
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1 Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis. Quinapril endothelin 1 Rattus norvegicus
2 In a normotensive model of immune-complex nephritis, in which there exists an increase in renal ACE activity, the effect of the ACE inhibitor quinapril on preproET-1 and ETA receptor mRNA expression, as well as on ET-1 protein levels, was examined in this study. Quinapril endothelin 1 Rattus norvegicus
3 The administration of the ACE inhibitor quinapril decreased proteinuria and morphological lesions, preproET-1 gene transcription, and ET-1 protein levels, as well as the ETA receptor mRNA. Quinapril endothelin 1 Rattus norvegicus
4 The results from this study show that in a normotensive model of immune-complex nephritis, there was an overexpression of ET-1 in several structures of the kidney that was downregulated by quinapril administration. Quinapril endothelin 1 Rattus norvegicus