Pub. Date : 1997 May
PMID : 9176845
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis. | Quinapril | endothelin 1 | Rattus norvegicus |
| 2 | In a normotensive model of immune-complex nephritis, in which there exists an increase in renal ACE activity, the effect of the ACE inhibitor quinapril on preproET-1 and ETA receptor mRNA expression, as well as on ET-1 protein levels, was examined in this study. | Quinapril | endothelin 1 | Rattus norvegicus |
| 3 | The administration of the ACE inhibitor quinapril decreased proteinuria and morphological lesions, preproET-1 gene transcription, and ET-1 protein levels, as well as the ETA receptor mRNA. | Quinapril | endothelin 1 | Rattus norvegicus |
| 4 | The results from this study show that in a normotensive model of immune-complex nephritis, there was an overexpression of ET-1 in several structures of the kidney that was downregulated by quinapril administration. | Quinapril | endothelin 1 | Rattus norvegicus |