Title : Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A.

Pub. Date : 1997 Apr 25

PMID : 9175724






2 Functional Relationships(s)
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1 Furthermore, indinavir selectively inhibited 6beta-hydroxylase activity of testosterone, a CYP3A marker activity, in rat and human liver microsomes; the interactions between testosterone and indinavir were competitive with Ki values of < 1.0 microM. Testosterone cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
2 Furthermore, indinavir selectively inhibited 6beta-hydroxylase activity of testosterone, a CYP3A marker activity, in rat and human liver microsomes; the interactions between testosterone and indinavir were competitive with Ki values of < 1.0 microM. Testosterone cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus