Pub. Date : 1997 Mar
PMID : 9172960
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. | Orphenadrine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The specificities of orphenadrine and methimazole on eight human liver P450 enzyme activities were evaluated by studying the extent of inhibition at different concentrations in two protocols: competitive inhibition and preincubation. | Orphenadrine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | In the competitive inhibition protocol, orphenadrine decreased CYP2B6 marker activity up to 45-57% in human liver microsomes and up to 80-97% in cell microsomes containing cDNA-expressed CYP2B6. | Orphenadrine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | In the competitive inhibition protocol, orphenadrine decreased CYP2B6 marker activity up to 45-57% in human liver microsomes and up to 80-97% in cell microsomes containing cDNA-expressed CYP2B6. | Orphenadrine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | In the preincubation protocol, orphenadrine decreased the CYP2B6 activity in cDNA-expressed cell microsomes to completion. | Orphenadrine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | In human liver microsomes, orphenadrine strongly decreased the marker activities of CYP2B6, CYP2D6, as well as CYP2C9; and partially decreased the marker activities of CYP1A2, CYP2A6, CYP3A4, and CYP2C19. | Orphenadrine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |