Title : Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes.

Pub. Date : 1997 Mar

PMID : 9172960






1 Functional Relationships(s)
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1 In the competitive inhibition protocol, methimazole had no effect on the marker activities of CYP2E1 and CYP2A6; slightly decreased CYP2D6 marker activity; partially decreased the marker activities of CYP2C19, CYP2C9, and CYP2B6; and dramatically decreased CYP3A4 marker activity. Methimazole cytochrome P450 family 2 subfamily C member 19 Homo sapiens