Pub. Date : 1997 Jun
PMID : 9166727
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 2 | GM1 enhances nerve growth factor (NGF)-stimulated neuritogenesis and prevents apoptotic death of PC12 cells; both may be due to enhancement of TrkA dimerization. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 3 | In this study, we examined the effect of GM1 on NGF-induced TrkA dimerization in Trk-PC12 (6-24) cells. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 4 | In this study, we examined the effect of GM1 on NGF-induced TrkA dimerization in Trk-PC12 (6-24) cells. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 5 | NGF increased tyrosine phosphorylation of the 140-kDa protein (TrkA monomer), and preincubation with GM1 potentiated this effect. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 6 | Our results suggest that GM1 is augmenting the effects of NGF on PC12 cells by enhancing the dimerization and activation of the TrkA receptor. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |