Title : Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells.

Pub. Date : 1997 Jun

PMID : 9165004






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To determine whether this effect of cAMP on cell growth was mediated by inhibition of the activity of extracellular signal-regulated kinases 1 and 2 (ERK1 and -2), two mitogen-activated protein kinases, the effect of cAMP on growth factor-induced ERK activity in MCF-7 cells was examined. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
2 To determine whether this effect of cAMP on cell growth was mediated by inhibition of the activity of extracellular signal-regulated kinases 1 and 2 (ERK1 and -2), two mitogen-activated protein kinases, the effect of cAMP on growth factor-induced ERK activity in MCF-7 cells was examined. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
3 Taken together with the effects of cAMP on IGF-I- and EGF-induced Elk-1 activation, these data suggest that the effect of cAMP on SRE activity occurs distal to ERK activation, possibly via inhibition of an ERK-independent pathway. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens