Title : Bidirectional regulation of two DNA-damage-inducible genes, MAG1 and DDI1, from Saccharomyces cerevisiae.

Pub. Date : 1997 Feb

PMID : 9157248






3 Functional Relationships(s)
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1 Like MAG1, the DDI1 gene is also controlled by an upstream repressing site (URS) located 5" to the direct repeat. Peptichemio Ddi1p Saccharomyces cerevisiae S288C
2 Based on this and previous studies, a model is proposed whereby the constitutive expression of MAG1 and DDI1 is controlled by two functionally opposite regulatory elements, UAS and URS, probably through an antagonistic mechanism, whereas the damage-induced expression appears to be regulated by mechanisms of derepression at the URS as well as activation at the UAS. Peptichemio Ddi1p Saccharomyces cerevisiae S288C
3 Based on this and previous studies, a model is proposed whereby the constitutive expression of MAG1 and DDI1 is controlled by two functionally opposite regulatory elements, UAS and URS, probably through an antagonistic mechanism, whereas the damage-induced expression appears to be regulated by mechanisms of derepression at the URS as well as activation at the UAS. Peptichemio Ddi1p Saccharomyces cerevisiae S288C