Pub. Date : 1997 May
PMID : 9155831
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Platelet-activating factor induces histamine release from human skin mast cells in vivo, which is reduced by local nerve blockade. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 2 | The purpose of this study was to investigate the extent and possible mechanisms of PAF-induced histamine release in human skin in vivo with the use of dermal microdialysis. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 3 | RESULTS: PAF, but not lyso-PAF, caused statistically significant dose-related histamine release and wheal and flare reactions. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 4 | CONCLUSIONS: These data suggest that PAF induced histamine release from mast cells in intact human skin indirectly via neurogenic activation. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 5 | Further, on the intradermal injection of PAF histamine release and the skin responses, the wheal and the flare, are differentially regulated by neurogenic components. | Histamine | PCNA clamp associated factor | Homo sapiens |