Title : Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.

Pub. Date : 1997 May

PMID : 9152603






1 Functional Relationships(s)
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1 Ketoconazole (< or = 2.0 microM) or troleadomycin, CYP3A-selective inhibitors, markedly decreased (> or = 99%) the formation of both metabolites, whereas inhibitors selective of other CYP forms were relatively ineffective (< or = 10% inhibition). Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens