Pub. Date : 1997 May 16
PMID : 9148915
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | The glucocorticoid receptor (GR) is bound to hsp90 via its hormone binding domain (HBD), which must be associated with hsp90 to have a steroid binding conformation. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | The glucocorticoid receptor (GR) is bound to hsp90 via its hormone binding domain (HBD), which must be associated with hsp90 to have a steroid binding conformation. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | In this work we show that when the GR is incubated with hsp90, hsp70, and p60, steroid binding sites are generated despite the absence of p23. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 7 | Our data suggest that hsp90, hsp70, and p60 work together as a chaperone complex that possesses all of the folding/unfolding activity necessary to generate the high affinity steroid binding conformation of the receptor. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |