Pub. Date : 1997 May 16
PMID : 9148901
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Since the generation of ceramide has been directly linked with the activation of the transcription factor, NFkappaB, this was investigated as a novel target for the action of daunorubicin. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Here we describe how treatment of HL-60 promyelocytes and Jurkat T lymphoma cells with daunorubicin results in the activation of the transcription factor NFkappaB. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Daunorubicin also induced IkappaB degradation and increased the expression of an NFkappaB-linked reporter gene. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | These data therefore suggest that the effect of daunorubicin on NFkappaB is unlikely to involve ceramide, but may involve reactive oxygen species generated as a result of endogenous cellular processes rather than reductive metabolism of the drug. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |