Title : CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose.

Pub. Date : 1997 May 16

PMID : 9148900






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 An additional enzymatic activity of CD38 shared by monofunctional ADP-ribosyl cyclase from Aplysia californica is the exchange of the base group of NAD+ (nicotinamide) with various nucleophiles. Niacinamide CD38 molecule Homo sapiens
2 Both human CD38 (either recombinant or purified from erythrocyte membranes) and Aplysia cyclase were found to catalyze the exchange of ADPR with the nicotinamide group of NAD+ leading to the formation of a dimeric ADPR ((ADPR)2). Niacinamide CD38 molecule Homo sapiens