Title : Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

Pub. Date : 1997 May

PMID : 9145912






1 Functional Relationships(s)
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1 In the treated cells, the intrinsic formation clearance of 1"-hydroxymidazolam (a reaction characteristically catalyzed by CYP3A enzymes) was estimated to be somewhat lower than that of human jejunal mucosa (1.14 and 3.67 ml/min/g of cells, respectively). 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens