Pub. Date : 1997 May
PMID : 9145845
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Metabolism of rifabutin and its 25-desacetyl metabolite, LM565, by human liver microsomes and recombinant human cytochrome P-450 3A4: relevance to clinical interaction with fluconazole. | 25-desacetylrifabutin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
2 | The metabolism of both rifabutin and LM565 was evaluated in human liver microsomes and recombinant human cytochrome P-450 (CYP) 3A4 in the presence of fluconazole and other probe drugs known to inhibit CYP groups 1A2, 2C9, 2D6, 2E1, and 3A. | 25-desacetylrifabutin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
3 | In addition, LM565 was readily metabolized by the recombinant CYP 3A4 to the same two products found with its metabolism by human microsomes. | 25-desacetylrifabutin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |