Title : Metabolism of rifabutin and its 25-desacetyl metabolite, LM565, by human liver microsomes and recombinant human cytochrome P-450 3A4: relevance to clinical interaction with fluconazole.

Pub. Date : 1997 May

PMID : 9145845






3 Functional Relationships(s)
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1 Metabolism of rifabutin and its 25-desacetyl metabolite, LM565, by human liver microsomes and recombinant human cytochrome P-450 3A4: relevance to clinical interaction with fluconazole. 25-desacetylrifabutin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The metabolism of both rifabutin and LM565 was evaluated in human liver microsomes and recombinant human cytochrome P-450 (CYP) 3A4 in the presence of fluconazole and other probe drugs known to inhibit CYP groups 1A2, 2C9, 2D6, 2E1, and 3A. 25-desacetylrifabutin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 In addition, LM565 was readily metabolized by the recombinant CYP 3A4 to the same two products found with its metabolism by human microsomes. 25-desacetylrifabutin cytochrome P450 family 3 subfamily A member 4 Homo sapiens