Title : Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes.

Pub. Date : 1997

PMID : 9143866






2 Functional Relationships(s)
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1 Quinidine and lignocaine, although they are substrates of CYP3A, showed preferential inhibition over the O-demethylation of codeine, suggesting a low affinity to the CYP3A. Lidocaine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Quinidine and lignocaine, although they are substrates of CYP3A, showed preferential inhibition over the O-demethylation of codeine, suggesting a low affinity to the CYP3A. Lidocaine cytochrome P450 family 3 subfamily A member 4 Homo sapiens