Title : Binding of malignant lymphoid cells to the white matter of the human central nervous system: role of different CD44 isoforms, beta 1, beta 2 and beta 7 integrins, and L-selectin.

Pub. Date : 1997 May

PMID : 9143269






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 A multifunctional adhesion molecule CD44 partially mediates binding of lymphocytes to the white matter by interacting with hyaluronate. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
2 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
3 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
4 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
5 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
6 (b) The only ligand of CD44 in the central nervous system (CNS) white matter is hyaluronate. hyaluronate CD44 molecule (Indian blood group) Homo sapiens