Title : Pathophysiological role of secretory type I and II phospholipase A2 in acute pancreatitis: an experimental study in rats.

Pub. Date : 1997 Mar

PMID : 9135530






4 Functional Relationships(s)
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1 SUBJECTS AND METHODS: Catalytic activities of secretory type I (pancreatic) and type II (non-pancreatic) PLA2 and the protein concentration of immunoreactive pancreatic PLA2 (IR-PLA2) in serum and pancreatic tissue of rats with cerulein (mild form) and sodium taurocholate (severe form) induced acute pancreatitis were determined. Taurocholic Acid phospholipase A2 group IB Rattus norvegicus
2 SUBJECTS AND METHODS: Catalytic activities of secretory type I (pancreatic) and type II (non-pancreatic) PLA2 and the protein concentration of immunoreactive pancreatic PLA2 (IR-PLA2) in serum and pancreatic tissue of rats with cerulein (mild form) and sodium taurocholate (severe form) induced acute pancreatitis were determined. Taurocholic Acid phospholipase A2 group IB Rattus norvegicus
3 In sodium taurocholate induced acute pancreatitis type II PLA2 activity significantly increased, reaching values over 10-fold higher than controls (p < 0.01), whereas IR-PLA2 protein concentration and type I PLA2 activity were only marginally increased. Taurocholic Acid phospholipase A2 group IB Rattus norvegicus
4 Type II PLA2 activity is significantly increased in sodium taurocholate induced acute pancreatitis indicating its role in the local necrotising process and involvement in the systemic effects in severe acute pancreatitis. Taurocholic Acid phospholipase A2 group IB Rattus norvegicus