Pub. Date : 1997 Apr 27
PMID : 9133470
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | iNOS expression in allografts resulted in elevated serum nitrite/nitrate levels, indicative of increased in vivo nitric oxide (NO) production. | Nitrates | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | CONCLUSIONS: (1) iNOS expression and increased NO production occurred during the early stages of acute rejection, persisted throughout the unmodified rejection process, and localized to infiltrating inflammatory cells, but not allograft parenchymal cells; (2) aminoguanidine ameliorated the histological and functional changes of acute rejection; and (3) increased NO production, detected by the presence of iNOS mRNA, protein, or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection. | Nitrates | nitric oxide synthase 2 | Rattus norvegicus |