Pub. Date : 1996 Dec
PMID : 9131406
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By using specific PKC inhibitors and down-regulation experiments we provide evidence that PKC alpha acts as a negative feedback regulator of ATP- and UTP-stimulated phosphoinositide turnover, whereas PKC epsilon triggers arachidonic acid release and subsequent prostaglandin synthesis and stimulates a phosphatidylcholine-hydrolysing phospholipase D. Moreover, PKC delta may activate the mitogen-activated protein kinase cascade and thus promote mesangial cell proliferation in response to extracellular ATP and <protein-id="291987">UTP. | Phosphatidylcholines | protein kinase C, alpha | Rattus norvegicus |
| 2 | By using specific PKC inhibitors and down-regulation experiments we provide evidence that PKC alpha acts as a negative feedback regulator of ATP- and UTP-stimulated phosphoinositide turnover, whereas PKC epsilon triggers arachidonic acid release and subsequent prostaglandin synthesis and stimulates a phosphatidylcholine-hydrolysing phospholipase D. Moreover, PKC delta may activate the mitogen-activated protein kinase cascade and thus promote mesangial cell proliferation in response to extracellular ATP and <protein-id="291987">UTP. | Phosphatidylcholines | protein kinase C, alpha | Rattus norvegicus |