Title : Does central obesity reflect "Cushing's disease of the omentum"?

Pub. Date : 1997 Apr 26

PMID : 9130942






3 Functional Relationships(s)
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1 Glucocorticoid hormone action is, in part, controlled by two isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) which interconverts hormonally active cortisol to inactive cortisone. Hydrocortisone hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens
2 Glucocorticoid hormone action is, in part, controlled by two isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) which interconverts hormonally active cortisol to inactive cortisone. Hydrocortisone hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens
3 INTERPRETATION: Adipose stromal cells from omental fat, but not subcutaneous fat, can generate active cortisol from inactive cortisone through the expression of 11 beta-HSD1. Hydrocortisone hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens