Title : Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole.

Pub. Date : 1977 Nov

PMID : 913025






1 Functional Relationships(s)
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1 It is suggested that phenylbutazone and oxyphenbutazone act by inducing form of cytochrome P-450 with low activity for tolbutamide hydroxylation, whereas sulfaphenazole acts by direct inhibition of the microsomal mixed function oxidase system. Tolbutamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens