Pub. Date : 1997 Apr
PMID : 9129996
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPS (20 micrograms/ml)-induced in vitro TNF-alpha production, measured by bioassay and enzyme-linked immunosorbent assay, was significantly inhibited with captopril, delapril and cilazapril in a concentration of 10(-3) mol/l. | Cilazapril | tumor necrosis factor | Homo sapiens |
| 2 | A single, oral administration of captopril, delapril and cilazapril at more than 10-fold doses of common clinical use in man significantly inhibited LPS (2 mg/kg)-induced serum TNF-alpha activity in Balb/c mice. | Cilazapril | tumor necrosis factor | Homo sapiens |
| 3 | These results indicate that ACE inhibitors such as captopril, delapril and cilazapril have an inhibitory effect on TNF-alpha production not only in vitro as previously reported, but also in vivo, although relatively high concentrations and large doses were required in this study. | Cilazapril | tumor necrosis factor | Homo sapiens |