Pub. Date : 1997 Mar 1
PMID : 9119028
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, H2O2 has been reported to stimulate the activity of the mitogen-activated protein kinases (MAPKs) ERK and JNK, and the expression of the proto-oncogenes c-fos and c-jun. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Moreover, the stimulation by H2O2 of ERK and JNK was decreased by phospholipase A2 activity inhibitors. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Although ERK was strongly and durably stimulated by 200 microM H2O2 in astrocytes, at the same extent as by mitogenic growth factors, basal thymidine incorporation rate was decreased by more than 80% after 12-15 h. Moreover, the stimulation of thymidine incorporation induced by basic fibroblast growth factor was transiently abolished by H2O2. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Although ERK was strongly and durably stimulated by 200 microM H2O2 in astrocytes, at the same extent as by mitogenic growth factors, basal thymidine incorporation rate was decreased by more than 80% after 12-15 h. Moreover, the stimulation of thymidine incorporation induced by basic fibroblast growth factor was transiently abolished by H2O2. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Furthermore, H2O2 likely induced the expression of CL100/PAC1/MKP-1, a dual specificity phosphatase which has been implicated in ERK and JNK inactivation in the nucleus. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |