Title : Role of IgE in hyperresponsiveness induced by passive sensitization of human airways.

Pub. Date : 1997 Mar

PMID : 9117014






4 Functional Relationships(s)
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1 Incubation of airways from nonatopic patients with serum from patients with high IgE levels confers responsiveness to "specific" (allergen) and hyperresponsiveness to "nonspecific" (histamine) stimuli. Histamine immunoglobulin heavy constant epsilon Homo sapiens
2 The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Histamine immunoglobulin heavy constant epsilon Homo sapiens
3 The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Histamine immunoglobulin heavy constant epsilon Homo sapiens
4 The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Histamine immunoglobulin heavy constant epsilon Homo sapiens