Title : Pharmacological characterization of protease-activated receptor (PAR-1) in rat astrocytes.

Pub. Date : 1997 Mar 26

PMID : 9105886






2 Functional Relationships(s)
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1 The effect of thrombin, TRAP-14 and A6Y on [3H]thymidine incorporation into DNA was significantly prevented by L9R, a 9-amino-acid peptide (Leu-Val-Arg-D-Cys-Gly-Lys-His-Ser-Arg; IC50 = 180 microM against thrombin and TRAP-14 and 800 microM against A6Y) previously described as an antagonist in human platelet aggregation. Thymidine coagulation factor II, thrombin Homo sapiens
2 The effect of thrombin, TRAP-14 and A6Y on [3H]thymidine incorporation into DNA was significantly prevented by L9R, a 9-amino-acid peptide (Leu-Val-Arg-D-Cys-Gly-Lys-His-Ser-Arg; IC50 = 180 microM against thrombin and TRAP-14 and 800 microM against A6Y) previously described as an antagonist in human platelet aggregation. Thymidine coagulation factor II, thrombin Homo sapiens