Pub. Date : 1997 Apr 15
PMID : 9103428
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506. | Tacrolimus | interleukin 2 | Homo sapiens |
| 2 | Our present findings clearly indicate that FK506-sensitive signaling molecules are involved in T cell IL-5 production induced by both TCR and IL-2 stimulation and suggest that IL-2 receptor signal leading to IL-5 gene transcription is transduced by a unique FK506-sensitive pathway other than the Ca2+-dependent signal transduction pathway, such as the calcineurin-NF-AT system. | Tacrolimus | interleukin 2 | Homo sapiens |
| 3 | Our present findings clearly indicate that FK506-sensitive signaling molecules are involved in T cell IL-5 production induced by both TCR and IL-2 stimulation and suggest that IL-2 receptor signal leading to IL-5 gene transcription is transduced by a unique FK506-sensitive pathway other than the Ca2+-dependent signal transduction pathway, such as the calcineurin-NF-AT system. | Tacrolimus | interleukin 2 | Homo sapiens |
| 4 | Our present findings clearly indicate that FK506-sensitive signaling molecules are involved in T cell IL-5 production induced by both TCR and IL-2 stimulation and suggest that IL-2 receptor signal leading to IL-5 gene transcription is transduced by a unique FK506-sensitive pathway other than the Ca2+-dependent signal transduction pathway, such as the calcineurin-NF-AT system. | Tacrolimus | interleukin 2 | Homo sapiens |