Title : Protective effect of liposomal alpha-tocopherol against bleomycin-induced lung injury.

Pub. Date : 1997 Mar

PMID : 9099426






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1 Results of this study showed that lungs of animals treated with bleomycin were seriously damaged, as evidenced by significant histological changes and increases in lung weight, lipid peroxidation, myeloperoxidase activity and hydroxyproline content as well as decreases in lung angiotensin converting enzyme (ACE) and alkaline phosphatase (AKP) activities. Bleomycin myeloperoxidase Rattus norvegicus
2 In contrast, pretreatment of rats with alpha-tocopherol liposomes 30 min prior to bleomycin administration resulted in little or no histological changes and conferred a significant protection against bleomycin-induced changes in edema, lipid peroxidation, hydroxyproline content, and ACE, AKP and myeloperoxidase activities. Bleomycin myeloperoxidase Rattus norvegicus