Title : Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

Pub. Date : 1997 Mar

PMID : 9084911






2 Functional Relationships(s)
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1 In the present study, the role of the major human GSTs in the conjugation of PGA2 and PGJ2 with GSH was investigated with purified enzymes, i.e., the Alpha-class enzymes GST A1-1 and GST A2-2, the Mu-class enzyme GST M1a-1a, and the Pi-class enzyme GST P1-1. 9-deoxy-delta-9-prostaglandin D2 glutathione S-transferase alpha 2 Homo sapiens
2 GSTA2-2 only showed some minor formation of the R-GSH conjugate of PGJ2. 9-deoxy-delta-9-prostaglandin D2 glutathione S-transferase alpha 2 Homo sapiens