Title : Troglitazone reduces contraction by inhibition of vascular smooth muscle cell Ca2+ currents and not endothelial nitric oxide production.

Pub. Date : 1997 Apr

PMID : 9075808






2 Functional Relationships(s)
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1 The insulin-sensitizing compound troglitazone has evolved into a promising therapeutic agent for type II diabetes. Troglitazone insulin Homo sapiens
2 Because troglitazone has insulin-like effects on a number of tissues, we hypothesized that it may reduce vascular tone through stimulation of endothelial-derived nitric oxide (NO) production or by diminution of vascular smooth muscle cell (VSMC) intracellular calcium ([Ca2+]i). Troglitazone insulin Homo sapiens