Title : Cross-talk between cellular signaling pathways activated by substance P and vasoactive intestinal peptide in rat lactotroph-enriched pituitary cell cultures.

Pub. Date : 1997 Apr

PMID : 9075734






3 Functional Relationships(s)
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Protein Name
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1 Down-regulation of PKC activity by long term 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment (24 h) diminished, but did not abolish, the effect of SP on VIP-stimulated cAMP production. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
2 Down-regulation of PKC activity by long term 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment (24 h) diminished, but did not abolish, the effect of SP on VIP-stimulated cAMP production. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
3 TPA, which translocates PKC alpha, beta, and delta in lactotrophs, had a synergistic effect on cAMP formation induced by VIP, but did also, unlike SP, display cAMP rising abilities when cells were not exposed to VIP and forskolin. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus