Title : Synthesis and biological activity of beta-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT.

Pub. Date : 1997 Feb

PMID : 9061205






1 Functional Relationships(s)
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1 Enzyme-catalyzed hydrolysis of the glucuronic acid moiety by human beta-glucuronidase results in the liberation of the parent drug paclitaxel via gamma or delta lactam formation with half-lives of 45 min and 2 h (1 and 2b). Glucuronic Acid glucuronidase beta Homo sapiens