Title : Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells.

Pub. Date : 1997 Feb 25

PMID : 9056422






1 Functional Relationships(s)
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1 We report here that overexpression of the IGF-IR did not modify sensitivity of cells to IGF-I; however, responsiveness to the ligand was moderately enhanced in most of the MCF-7/IGF-IR clones (measured by [3H]thymidine incorporation into DNA). Tritium insulin like growth factor 1 Homo sapiens