Title : Steroid modulation of neuropeptide Y-induced luteinizing hormone releasing hormone release from median eminence fragments from male rats.

Pub. Date : 1996 Feb

PMID : 9053775






3 Functional Relationships(s)
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1 In female rats, NPY facilitation of LHRH release is greatly augmented in advance of preovulatory LHRH surges, likely via the actions of ovarian steroids. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
2 These results demonstrate that NPY stimulates LHRH release from the hypothalamus in vitro, and that gonadal steroids, in this case T and/or its metabolites, modulate the responsiveness of the LHRH neuron to NPY. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
3 Based on these data from intact and castrate-derived tissues, it appears that steroids are necessary to maintain LHRH responsiveness to NPY receptor stimulation. Steroids gonadotropin releasing hormone 1 Rattus norvegicus