Title : Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1.

Pub. Date : 1997 Feb

PMID : 9051721






1 Functional Relationships(s)
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1 These bisphosphonates had essentially similar effects on growth and the osteoblastic functions of the cells, i.e., they had no inhibitory effects on cell growth except at higher concentrations, they increased ALP activity, and inhibited PGE2 production. Diphosphonates alkaline phosphatase, placental Homo sapiens