Pub. Date : 1997
PMID : 9049577
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of enalapril and quinapril on forearm vascular ACE in man. | Quinapril | angiotensin I converting enzyme | Homo sapiens |
| 2 | Quinapril appears to be amongst the more effective inhibitors of vascular tissue ACE in vitro. | Quinapril | angiotensin I converting enzyme | Homo sapiens |
| 3 | This study assesses the in vivo effect of single oral doses of quinapril and enalapril, in attenuating the vasoconstrictive action of angiotensin I (AI) (which we have previously shown depends on its conversion to angiotensin II (AII) by vascular ACE) in the forearm resistance vessels of man. | Quinapril | angiotensin I converting enzyme | Homo sapiens |
| 4 | Both quinapril and enalapril produced a similar degree of plasma ACE inhibition reducing concentrations to 2.8 U.l-1 and 2.6 U.l-1 respectively. | Quinapril | angiotensin I converting enzyme | Homo sapiens |
| 5 | CONCLUSION: These results indicate that when quinapril and enalapril are administered as single 20 mg doses, each of which produces the same degree of plasma ACE inhibition and blood pressure reduction- quinapril inhibits vascular ACE to a greater degree than both enalapril and placebo. | Quinapril | angiotensin I converting enzyme | Homo sapiens |
| 6 | CONCLUSION: These results indicate that when quinapril and enalapril are administered as single 20 mg doses, each of which produces the same degree of plasma ACE inhibition and blood pressure reduction- quinapril inhibits vascular ACE to a greater degree than both enalapril and placebo. | Quinapril | angiotensin I converting enzyme | Homo sapiens |
| 7 | CONCLUSION: These results indicate that when quinapril and enalapril are administered as single 20 mg doses, each of which produces the same degree of plasma ACE inhibition and blood pressure reduction- quinapril inhibits vascular ACE to a greater degree than both enalapril and placebo. | Quinapril | angiotensin I converting enzyme | Homo sapiens |