Pub. Date : 1997 Feb
PMID : 9041054
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium. | Calcium | interleukin 6 | Homo sapiens |
| 2 | We recently reported that the calcium concentration in plasma affects IL-6 secretion from mononuclear blood cells. | Calcium | interleukin 6 | Homo sapiens |
| 3 | To investigate the underlying mechanism, we have studied the effect of calcium on IL-6 formation in mononuclear blood cells ex vivo and in vitro. | Calcium | interleukin 6 | Homo sapiens |
| 4 | IL-6 secretion ex vivo from mononuclear blood cells drawn 4 h after calcium intake was increased 185% as compared with IL-6 secretion from cells drawn just before calcium intake. | Calcium | interleukin 6 | Homo sapiens |
| 5 | IL-6 secretion ex vivo from mononuclear blood cells drawn 4 h after calcium intake was increased 185% as compared with IL-6 secretion from cells drawn just before calcium intake. | Calcium | interleukin 6 | Homo sapiens |
| 6 | In vitro studies revealed that stimulation of isolated mononuclear blood cells with physiological concentrations of calcium dose-dependently increased IL-6 secretion with an estimated EC50 at 1.2 mM Ca2+. | Calcium | interleukin 6 | Homo sapiens |
| 7 | These observations demonstrate that the plasma calcium concentration affects IL-6 secretion from mononuclear blood cells. | Calcium | interleukin 6 | Homo sapiens |