Title : Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

Pub. Date : 1997 Feb 28

PMID : 9038218






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The mutant P-glycoprotein has a decreased affinity for PSC 833 and vinblastine and a decreased ability to transport rhodamine 123. Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens
2 These data suggest that Phe335 is an important binding site on P-glycoprotein for substrates such as dactinomycin and vinblastine and for inhibitors such as cyclosporine and PSC 833. Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens