Title : Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha.

Pub. Date : 1997 Mar 1

PMID : 9036989






1 Functional Relationships(s)
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1 During engagement of the type I IFN receptor, IRS-1 is phosphorylated on tyrosine and associates with the p85 regulatory subunit of the phosphatidylinositol (PI) 3"-kinase, which is a dual-specificity enzyme possessing both lipid and serine kinase activities. Phosphatidylinositols insulin receptor substrate 1 Homo sapiens