Title : Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones.

Pub. Date : 1997 Mar 1

PMID : 9036942






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 3,4-Dichloroisocoumarin, a serine-protease inhibitor that efficiently inhibits granzyme B and poorly inhibits granzyme A, had similar effects as Ac-DEVD-CHO on anti-CD3 mAb-redirected lysis of L1210 cells. 3,4-dichloroisocoumarin granzyme B Mus musculus