Title : Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation: production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1.

Pub. Date : 1997 Feb

PMID : 9029046






3 Functional Relationships(s)
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1 Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation: production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1. Phenobarbital UDP glucuronosyltransferase family 2 member B17 Rattus norvegicus
2 Using isoform-specific antipeptide antibodies, both UGT1.1r and UGT2B1 in Wistar and Sprague-Dawley rats were inducible by PB treatment. Phenobarbital UDP glucuronosyltransferase family 2 member B17 Rattus norvegicus
3 This study is the first demonstration that protein levels of two morphine UGT isoforms, UGT1.1r and UGT2B1, in the liver of Wistar and Sprague-Dawley rats are inducible by PB treatment. Phenobarbital UDP glucuronosyltransferase family 2 member B17 Rattus norvegicus