Title : Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases.

Pub. Date : 1997 Feb

PMID : 9029042






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 1 microM of the CYP3A inhibitor ketoconazole inhibited 37 +/- 19% of the N-demethylation and 86 +/- 5% of 3-hydroxylation. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens