Title : Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species.

Pub. Date : 1997 Feb

PMID : 9027728






4 Functional Relationships(s)
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1 We have recently proposed a H2O2-generating b-type cytochrome as part of the cellular oxygen sensor that controls O2-dependent erythropoietin (Epo) production in the human hepatocellular carcinoma cell line HepG2. Hydrogen Peroxide erythropoietin Homo sapiens
2 We have recently proposed a H2O2-generating b-type cytochrome as part of the cellular oxygen sensor that controls O2-dependent erythropoietin (Epo) production in the human hepatocellular carcinoma cell line HepG2. Hydrogen Peroxide erythropoietin Homo sapiens
3 High cellular levels of H2O2 inhibit hypoxia-induced Epo production while low levels-as under hypoxic conditions-allow full expression of the Epo gene. Hydrogen Peroxide erythropoietin Homo sapiens
4 The inhibition of Epo production by exogenous H2O2 was completely antagonized by DSF. Hydrogen Peroxide erythropoietin Homo sapiens